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All of these answers should be true. Two gene products are associated with each other in a functional complex (that has been modeled), and the resulting complex is necessary for cell survival. The gene product located at the top of the list (Rank 1) is the substrate for the protein product at the bottom of the list (Rank 1).
These answers are not true because a) Protein A and Protein B interact with Protein C. b) Protein B regulates the activity of Protein D. c) Protein B and Protein D are components of the same complex (that has been modeled), and the resulting complex is necessary for cell survival. d) Protein B and Protein D do not interact with Protein C.
Examining expression data in humans and other organisms with the help of chromosome conformation capture (4C) technology is a promising approach to identify associations between genetic variations and protein expression levels.4C allows mapping of putative binding sites and the 3C method allows determination of the number of breakpoints (constraints) between them.4C technology has been successfully used to study chromatin structure, gene expression and transcription factors in the brain [162]. Our current work is focused on integrating the transcriptional profiles of human and fly’s brain across different sexes, ages and brain regions by using human and fly microarrays (see Table 1). Each gene was represented in the analysis as a single cross-species probe and the probes were compared for differential expression on the basis of variance analysis and fold change filter. This was done using a mixed effects model.
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